Siddhartha Medical College, Vijayawada was established by Siddhartha Academy of General and Technical Education, Vijayawada in November, 1980 with an annual  intake of 100 students.

As this is a statewide college admissions will be done following six point formula.

The then  Hon'ble Chief Minister of Andhra Pradesh late Sri.T.Anjaiah inaugurated the college on 13-3 1981.and the regular session started from 16.3.1981.

The A.P. University of  Health Sciences was established  in the year 1986 in Vijayawada by the Government of Andhra Pradesh. Siddhartha Medical College was handed over by the Siddhartha Academy of General & Technical Education to the A.P. University of  Health Sciences on 21st  December, 1986. 

The Government of Andhra Pradesh has de-linked the college from NTR University of Health Sciences on 21st December 2000 , and brought this college under the administrative control of Director of Medical Education.