R. G. Kar Medical College & Hospital, Kolkata was established in 1886 as Calcutta School of Medicine.

Thus in the same year, Calcutta Medical School came into existence.

Later, it merged with another nationalist organization' College of Physicians and Surgeons of Bengal ' and the Belgachia Medical College ' came into being in 1916.

It was inaugurated by the then Governor of Bengal Lord Carmichael with its first batch of 48 students.

After the demise of Dr. Radh Govinda Kar, the college was named after him.

The ex-students' association was formed in 1932 and the first re-union took place under the presidency of Prafulla Bhusan Basu.