Noble College, Machilipatnam is one of the oldest Institutions in India started by Christian Missionaries. Noble started its journey as a school founded in 1843 by Rev.Robert Turlington Noble, who was sent by Church Missionary Society in England for Education and Evangelistic works. In 1864, Noble school was raised to the College grade, with an affiliation to Madras University.

The institute witnessed its heydays in South India until 1938. Later, Lindsay Commission (1938) suggested that Noble College, Machilipatnam and Andhra Christian College, Guntur should be merged and a united College be started at Vijayawada. Consequently, Noble College was closed in 1938, but the proposed College at Vijayawada was never opened.

In May 1966, Rt. Rev. Dr. N.D. Anandarao Samuel, the then Bishop in Krishna-Godavari Diocese, attempted to bring the college back to life. The University and Government gave the approval and the College began functioning from July 1966 with Sri.A.F. Thyagaraju, M.A. (London) as its first Principal. The College was formally inaugurated on 27th August 1966 by Sri. Kasu Brahmananda Reddy the Honorable Chief Minister of Andhra Pradesh and the former student of Noble College. Sri.B.V.Subba Reddy the then speaker of the Legislative Assembly of Andhra Pradesh & former student presided over the function. Professor K.R.Srinivasa Ayyangar, the then Vice-Chancellor of Andhra University delivered the inaugural address.

In these 41 years, the College has been successful in regaining its reputation as a leading educational institution, serving all sections of community. Post-Graduate Courses like M.Sc., (Mathematics) and M.Sc., (Chemistry) were started in the year 2003-2004. The college seems to be determined to grow from strength to strength catering to the contemporary needs in the field of education under the leadership of its Chairman and Correspondent Rt. Rev. Dr. Govada Dyvasirvadam, M.A., M.Th., Ph.D., who is the proud alumnus of the institution.

The revived Noble College was affiliated to Andhra University up to 1985. From 1985-86 onwards it is affiliated to Acharya Nagarjuna University.