A.P. Sen Memorial Girls P.G College, Lucknow was establish in 1902 managed under the name Mahakali Pathshala.

The College was given recognition under the name Harimati Balika Vidyalay. The aim of the college was to provide education to Bengali in their own language.

In 1933, the college received temporary recognition for High School and Intermediate from U.P. Board. It was at this time it acquire the name Jubilee-girls School. The girls institution has been fortunate to have received the patronage of such eminent Personalities as L.M Jopling (City Magistrate) & M.F.A. Richardson as (Inspector of Schools). In 1944, the school received permanent recognition for High School. the college advanced to an Inter College in 1947 and to a degree college in 1955.

Since the time the college has been affiliated to the Lucknow University. The College has been contributing to the education of girls. It was with the initiative of the first principal, late (Miss) Been Dutta, that the college advanced from a primary school to a renowned degree college of the city. She is remembered even today for her love of discipline for her colleagues as well as her students. Right from the beginning, the Management Committee of the college had members who are renowned not only in the city but throughout the world, Such as Dr. Radha Kumud Mukherjee, Shri A.C. Banerjee, Dr. Radhal Kamal Mukherjee, Dr. Avinash Chandra Chatterjee etc. Various progressive citizens of lucknow have contributed to the development of the college through financial assistance. Among the well wishes of the college, the name that stands out is that of an eminent advocate and educationist of the city - the great poet, Late Shri Atul Prashad Sen. In order to immortalize his memory the colege was renamed as A.P. Sen Memorial Girls College. Shri A.P. Sen was a great Philanthropist, Social worker, educationist and literateur.

Located in Charbagh, the college has the campus area of 2.45 Acres. The builtup area is 3860 square meter. A well equipped library with a seating capacity of 80 students is housed in 2820 square feet. Text books and reference books are available in the library. The college has 5 computers and internet facilities. Apart from 15 class rooms (at present) there is faculty of teachers staff room, common room for students, rest rooms, vehicle parking, canteen, telephone, first aid. Apart from these physical facilities, the college has various committees compromising of 3-4 teachers each dealing with various aspects for the development of the Institution. Some of them Internal Quality Assurance Cell, Grievance Redressal Cell. Aids Awareness Cell, Career Counselling Cell, Alumni Association, Parents - Teachers Association, Students Government Association, Academic Author. For Units of NSS and one unit of NCC are active in the college.