Government Medical College (GMC), Thrissur was established in 1982.

The college was formally inaugurated on April 1, 1982 by the Honourable Governor of Kerala, Smt.Jyothi Vencatachellum, who had also laid the foundation stone for the proposed college building at Mulagunnathukavu on 30 April 1982. Govt.Medical College, Thrissur had its humble beginning at Mannuthy.

The clinical departments started functioning on 22 October 1983 in the erstwhile District Hospital & Maternity Hospital buildings in Thrissur town.

In April 1, 1985, the entire District Hospital was taken over on 1 April 1985. Construction of the 300 bedded Medical College Chest Hospital at Mulagunnathukavu was completed in 1987.

The primary health centre of Tholur was taken over by the college in 1986, for regular training of medical students in community and preventive care. Ollur & Erumappetty primary health centres were also made available for training purposes.